During the course of the game, an alien invasion takes place, lead by cybernetic beings dubbed the Bio-Mecha. Gamera joins forces with the international organization called the Science Defense Academy against the invaders, who soon counterattack with the creation of the Neo-Gyaos; mutant variants of Gamera's winged nemesis Gyaos, of numerous shapes, sizes, and destructive capabilities.
The game contains several live-action cutscenes with actors. The game can be heard in English or in Japanese, with Japanese subtitles.
In the game, the player is part of the United Nations Military, who can loosely command Gamera to attack enemies, as well as having the power to attack with the player's ship's laser. Gamera is far more powerful, however.
The game plays somewhat like a rail-gun game, as most of the stages are relatively linear. The game travels through a variety of settings, such as cities, oceans, forests and caves.
With some exceptions (Gyaos Man, Quicksilver, M-Machine-Dread VII, Bionic Gyaos, St. Millennium, etc.), the majority of the game's original enemies' official names are unknown to Western audiences. The following lists utilize descriptive names for the enemies whose real names are unknown, based on the characters' appearances and abilities.
Neo-Gyaos are the genetically engineered, custom built "attack beasts" of the Bio-Mecha created from the genes of Super Gyaos, which the aliens had stolen from the Science Defense Academy. The final Neo-Gyaos monster, the colossal Bionic Gyaos, also known as the Dragon Fortress, is a threefold hybrid of Gyaos and Gamera DNA along with Bio-Mecha technology.
- Gyaos;Man (Kind)
- G;Bionic Gyaos (Dragon Fortress)
- Gyaos Soldier
- Gyaos 3
The alien invaders behind the Neo-Gyaos are cybernetic entities, often appearing as gigantic robots or robotic vehicles, who share Gyaos genes in their biological half. The written language and communication of the Bio-Mecha is the same as the Etrurian runes found on the atoll in which Gamera was entombed, suggesting a possible connection between the Bio-Mecha and the Atlantean civilization. Major Bio-Mecha enemies are as follows:
- UFO (Bio-Mecha Mothership)
- M-Machine-Dread VII
- St. Millennium
- Quicksilver (Dolphind)
- Nomad Viper
- Nomad Chip
- Hover-blockade drones (separated units & combined)
- Saucer drones
- Sea speeders
- Forest walkers
- Beam-barrier drones
- Forest drones
This is a list of references for Gamera: 2000. These citations are used to identify the reliable sources on which this article is based. These references appear inside articles in the form of superscript numbers, which look like this: 
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